Naltrexone is a prescription medication used as part of care for alcohol use disorder. Like any medication, it can cause side effects. Most are mild and happen more often when starting. A licensed clinician reviews your health before prescribing and explains what to watch for.
Common side effects
Some people report nausea, headache, dizziness, fatigue, trouble sleeping, anxiety, or stomach discomfort, especially in the first days or weeks. These often ease over time. Taking the medication as a clinician directs and reporting how you feel at follow-up helps the clinician adjust the plan.
Less common effects
Liver-related effects are possible, which is one reason a clinician reviews liver history and may order laboratory testing. Allergic reactions are uncommon but possible. A clinician explains which signs need prompt attention.
The opioid warning
Naltrexone blocks opioid receptors. This is the most important safety point. If you use opioids or need opioid pain medicine, naltrexone can interfere with them or trigger opioid withdrawal. Tell the clinician about every medication and substance you use before starting, and carry information that you take naltrexone in case you need emergency care. For background on how a clinician reviews the medication, see how Seriva works.
When to contact a clinician
Contact a clinician about side effects that are severe, that do not go away, or that worry you. Signs such as yellowing of the skin or eyes, dark urine, severe stomach pain, or a reaction with swelling or trouble breathing need prompt medical attention.
Severe alcohol withdrawal is a medical emergency. Symptoms such as confusion, seizures, a racing heart, or hallucinations require immediate help. Naltrexone does not treat withdrawal and is not a substitute for emergency care.
Common questions
Do side effects mean I should stop the medication? Talk to a clinician before stopping or changing a dose. Many side effects are mild and ease over time, and a clinician can advise on the right step.
Can I take naltrexone with opioid pain medicine? No. Naltrexone blocks opioid receptors and can interfere with opioid pain medicines or trigger withdrawal. Tell the clinician about any opioid use first.
Does naltrexone affect the liver? Liver-related effects are possible. A clinician reviews liver history and may order laboratory testing before and during care.
Sources
- U.S. Food and Drug Administration, naltrexone drug labeling: FDA Drugs
- National Institute on Alcohol Abuse and Alcoholism (NIAAA): niaaa.nih.gov