The Sinclair Method is a protocol that uses naltrexone in a specific way: a person takes the medication before drinking rather than on a fixed daily schedule. It is named after the researcher who studied this approach. It is a clinician-directed protocol, which means a licensed clinician decides whether it is appropriate and how to use it.
The idea behind it
Naltrexone blocks opioid receptors. The Sinclair Method is built on the idea of targeted extinction: by taking naltrexone before drinking, the protocol aims to reduce the reinforcement a person associates with alcohol over time. This is a general-education description, not a promise about any individual outcome. Results differ from person to person.
It is still naltrexone
The Sinclair Method uses the same medication, naltrexone, so the same safety considerations apply. Naltrexone interferes with opioid pain medicines and can trigger withdrawal in someone using opioids. A clinician reviews medications, opioid use, liver history, and other health information first. Side effects are covered in naltrexone side effects: what to know.
A clinician directs the protocol
Whether the Sinclair Method is appropriate, how to dose it, and how to follow up are decisions a clinician makes with the patient. It is one of several ways naltrexone may be used. To see how an online clinician review works, read how Seriva works.
This protocol is for people who want to drink less or stop. It is not a substitute for emergency care. Anyone who may be experiencing severe alcohol withdrawal should seek urgent medical attention.
Common questions
How is the Sinclair Method different from daily naltrexone? The medication is the same. The difference is timing: the Sinclair Method involves taking naltrexone before drinking, on a clinician's direction, rather than on a fixed daily schedule.
Do I have to stop drinking to start? The protocol is structured around taking the medication before drinking. A clinician explains how it fits your goals and whether it is appropriate for you.
Is the Sinclair Method right for everyone? No. It is one approach among several, and a clinician decides whether it suits an individual.
Sources
- U.S. Food and Drug Administration, naltrexone drug labeling: FDA Drugs
- National Institute on Alcohol Abuse and Alcoholism (NIAAA): niaaa.nih.gov